You are viewing the site in preview mode

Skip to main content

Table 2 TAs and arsenic speciation of patients and healthy control

From: Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide

  TAs (ng/g) iAsIII% iAsV% MMA% DMA% PMI SMI
Plasma
 Patients 6.43 ± 1.56 11.40 ± 9.98 44.47 ± 19.81 17.19 ± 13.39 24.50 ± 15.47 0.25 (0–5.04) 1.75 (0.06–37.14)
 Control 8.99 ± 1.14 33.87 ± 18.92 25.26 ± 16.56 19.29 ± 14.53 16.13 ± 13.03 0.28 (0–8.74) 0.82 (0–19.2)
 P value < 0.001 < 0.001 < 0.001 0.28 < 0.001 0.742 0.002
Urine
 Patients 45.28 ± 33.28 40.08 ± 28.90 8.72 ± 11.42 15.64 ± 14.05 26.36 ± 26.64 0.27 (0–5.52) 1.21 (0–143.01)
 Control 57.55 ± 33.61 1.94 ± 7.19 1.37 ± 6.31 2.49 ± 3.52 78.92 ± 18.79 0.27 (0–1.24) 16.36 (3.32–120.34)
 P value 0.009 < 0.001 < 0.001 < 0.001 < 0.001 0.001 < 0.001
Hair
 Patients 195.43 ± 202.25 29.25 ± 16.44 34.26 ± 20.82 12.05 ± 12.95 18.87 ± 11.95 0.13 (0–2.16) 1.35 (0–91.46)
 Control 198.23 ± 133.16 13.29 ± 26.54 53.00 ± 48.00 14.93 ± 35.01 12.57 ± 26.58 0 (0–0.21) 0 (0–0.01)
 P value 0.96 0.002 0.012 0.558 0.132 0.001 0.007
Nails
 Patients 294.65 ± 158.94 30.21 ± 16.70 32.85 ± 18.08 17.70 ± 12.08 15.72 ± 10.14 0.24 (0–2.64) 0.84 (0–9)
 Control 338.80 ± 212.27 13.64 ± 30.55 20.07 ± 35.56 8.71 ± 26.27 52.57 ± 44.26 0 (0–0.45) 0.35 (0–0.69)
 P value 0.353 0.003 0.034 0.032 < 0.001 0.002 0.514
  1. TAs: total arsenic; iAsIII%: inorganic arsenite/TAs × 100%; iAsV%: inorganic arsenate/TAs × 100%; MMA%: monomethylarsonic acid/TAs × 100%; DMA%: dimethylarsinic acid/TAs × 100%; PMI: primary methylation index; SMI: secondary methylation index