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|
SNPsa
|
TAs (ng/mL)
|
iAsIII%
|
iAsV%
|
MMA%
|
DMA%
|
PMI
|
SMI
|
|---|
|
9749
|
|
AA
|
43.66 ± 35.79
|
41.16 ± 31.22
|
10.55 ± 13.83
|
16.54 ± 13.44
|
23.39 ± 24.27
|
0.21 (0.02–2.39)
|
1.05 (0–41.17)
|
|
AG & GG
|
41.61 ± 30.20
|
29.04 ± 30.13
|
5.54 ± 6.39
|
5.96 ± 3.64
|
46.45 ± 33.32
|
0.21 (0.02–1.33)
|
7.5 (0–29.06)
|
|
P value
|
0.874
|
0.294
|
0.296
|
0.024
|
0.02
|
0.989
|
0.011
|
|
27215
|
|
AA
|
41.66 ± 30.47
|
43.23 ± 30.00
|
9.09 ± 12.62
|
15.69 ± 13.04
|
23.11 ± 23.08
|
0.20 (0.02–2.39)
|
0.96 (0–143.01)
|
|
AG & GG
|
54.73 ± 39.34
|
23.73 ± 27.78
|
6.29 ± 6.38
|
9.42 ± 14.73
|
41.65 ± 34.93
|
0.26 (0.02–1.53)
|
6.41 (0–41.17)
|
|
P value
|
0.209
|
0.044
|
0.458
|
0.147
|
0.027
|
0.71
|
0.017
|
- SNP: single nucleotide polymorphism; AS3MT: (+ 3 oxidative state) methylation transferase; TAs: total arsenic; iAsIII%: inorganic arsenite/TAs × 100%; iAsV%: inorganic arsenate/TAs × 100%; MMA%: monomethylarsonic acid/TAs × 100%; DMA%: dimethylarsinic acid/TAs × 100%. PMI: primary methylation index; SMI: secondary methylation index
- aAll the other SNPs of AS3MT showed no significant influence on arsenic metabolism, therefore only A9749G and A27215G are presented
